{"id":48,"date":"2021-07-04T06:02:03","date_gmt":"2021-07-04T06:02:03","guid":{"rendered":"https:\/\/taiwancosmetic.org\/?p=48"},"modified":"2021-07-04T06:04:56","modified_gmt":"2021-07-04T06:04:56","slug":"%e6%83%85%e7%b7%92%e8%88%87%e7%9a%ae%e8%86%9a%e7%be%8e%e5%ae%b9%ef%bc%9acb2-skin","status":"publish","type":"post","link":"https:\/\/taiwancosmetic.org\/?p=48","title":{"rendered":"\u60c5\u7dd2\u8207\u76ae\u819a\u7f8e\u5bb9\uff1aCB2-skin\u2122"},"content":{"rendered":"

\u6295\u7a3f\u6587\u7ae0\uff0c\u4f5c\u8005:\u4e9e\u4ec0\u862d\u5168\u7403\u63a7\u80a1\u516c\u53f8\u3002<\/span><\/p>\n

\u4eba\u9ad4\u76ae\u819a\u53d7\u5230\u795e\u7d93\u652f\u914d\uff0c\u4e5f\u8207\u795e\u7d93\u7cfb\u7d71\u6709\u8457\u975e\u5e38\u7dca\u5bc6\u7684\u95dc\u4fc2\uff3b<\/sup>1<\/sup>\uff3d<\/sup>\u3002\u6240\u4ee5\uff0c\u8d8a\u4f86\u8d8a\u591a\u7684\u7814\u7a76\u8868\u660e\uff1a\u76ae\u819a\u7f8e\u5bb9\u5b78\u8207\u76ae\u819a\u795e\u7d93\u751f\u7269\u5b78\u6709\u8457\u9ad8\u5ea6\u76f8\u95dc\u6027\uff0c\u5982\uff1a\u5149\u8001\u5316\u3001\u76ae\u819a\u8272\u7d20\u7570\u5e38\u3001\u812b\u9aee\u7b49\u5747\u8207\u795e\u7d93\u4ecb\u8cea\uff08\u5982\u795e\u7d93\u71df\u990a\u7d20\u3001\u795e\u7d93\u80bd\u53ca\u5167\u5561\u80bd\u7b49\uff09\u4f5c\u7528\u6709\u95dc\uff3b<\/sup>2<\/sup>\uff3d<\/sup>\u3002\u5176\u4e2d\uff0c\u4eba\u9ad4\u76ae\u819a\u6240\u5177\u6709\u7684\u5b8c\u6574\u7684\u5167\u6e90\u6027\u5927\u9ebb\u7d20\u7cfb\u7d71\uff0c\u53c3\u8207\u5230\u76ae\u819a\u5167\u7a69\u614b\u5e73\u8861\u3001\u514d\u75ab\u529f\u80fd\u548c\u77e5\u89ba\u611f\u53d7\u3002\u96a8\u8457\u5e74\u9f61\u589e\u9577\u4ee5\u53ca\u5916\u6e90\u6027\u7684\u58d3\u529b\uff08\u7d2b\u5916\u6216\u8005\u6bd2\u7d20\u7b49\uff09\u7684\u589e\u52a0\uff0c\u5927\u9ebb\u7d20\u7cfb\u7d71\u7684\u555f\u52d5\u548c\u5e73\u8861\u6703\u53d7\u5230\u5f71\u97ff\uff0c\u5f9e\u800c\u6539\u8b8a\u7d30\u80de\u708e\u75c7\u56e0\u6578\u7684\u5408\u6210\u548c\u8fa3\u6912\u7d20\u53d7\u9ad4\uff08TRPV1\uff09\u7684\u8868\u9054\u3002<\/p>\n

\u57fa\u65bc\u5c0d\u4eba\u9ad4\u76ae\u819a\u5167\u6e90\u6027\u5927\u9ebb\u7d20\u7cfb\u7d71\u7684\u9818\u5148\u7814\u7a76\uff0c\u4e9e\u4ec0\u862d\u6cd5\u570bVincience\u2122\u7814\u767c\u4e2d\u5fc3\u63a1\u7528\u53ef\u6301\u7e8c\u7684\u683d\u57f9\u65b9\u5f0f\u548c\u74b0\u4fdd\u7684\u63d0\u53d6\u6280\u8853\uff0c\u8403\u53d6\u4e86\u54e5\u502b\u6bd4\u4e9e\u5ee3\u85ff\u9999\u8449\u4e2d\u7684\u6cb9\u6eb6\u6027\u6d3b\u6027\u6210\u5206\u2014\u2014\u5373CB2-skin\u2122\u751f\u7269\u529f\u80fd\u6027\u539f\u6599\u3002\u4f5c\u70ba\u5ee3\u85ff\u9999\u8449\u63d0\u53d6\u7269\uff0cCB2-skin\u2122\u4e0d\u50c5\u5bcc\u542b\u690d\u7269\u753e\u9187\uff0c\u8102\u80aa\u9178\u548c\u591a\u915a\uff0c\u4e5f\u662f\u7368\u7279\u7684\u76ae\u819a\u5927\u9ebb\u7d20\u53d7\u9ad42\uff08cb2\uff09\u555f\u52d5\u5291\u3002\u7814\u7a76\u8868\u660e\uff0cCB2-skin\u2122\u5ee3\u85ff\u9999\u8449\u63d0\u53d6\u7269\u80fd\u7279\u7570\u6027\u5730\u555f\u52d5\u76ae\u819a\u5927\u9ebb\u7d20\u53d7\u9ad42\uff0c\u4ee4\u808c\u819a\u6709\u6548\u6e1b\u5c11\u56e0\u74b0\u5883\u58d3\u529b\u7522\u751f\u76ae\u819a\u654f\u611f\u548c\u708e\u75c7\u7684\u53ef\u80fd\uff0c\u540c\u6642\u4fc3\u9032\u808c\u9ad4\u03b2-\u5167\u5561\u80bd\u7684\u5408\u6210\uff0c\u5f9e\u800c\u5feb\u901f\u9ad8\u6548\u5730\u61c9\u5c0d\u654f\u611f\u53cd\u61c9\uff0c\u9054\u5230\u8212\u7de9\u808c\u819a\u7684\u6548\u679c\u3002<\/p>\n

\"\"<\/p>\n

\u57161-\u4e9e\u4ec0\u862dCB2-skin\u2122\uff1a\u5f9e\u683d\u57f9\u5230\u984f\u808c<\/p>\n

\u6fc0\u6d3b<\/strong><\/span>CB2<\/strong>\u53d7\u9ad4\uff0c<\/strong>CBD<\/strong>\uff08\u5927\u9ebb\u4e8c\u915a\uff09\u884d\u751f\u7269\u7684\u6709\u6548\u66ff\u4ee3\u7269<\/strong><\/span><\/p>\n

ECS\u5167\u6e90\u6027\u5927\u9ebb\u7d20\u7cfb\u7d71\u88ab\u767c\u73fe\u65bc20\u4e16\u7d0080\u5e74\u4ee3\u672b\uff0c\u662f\u4eba\u9ad4\u6700\u5927\u7684\u795e\u7d93\u905e\u8cea\u7db2\u8def\u4e4b\u4e00\u3002\u5728\u5916\u90e8\u74b0\u5883\u8b8a\u5316\u6642\uff0c\u4ee5\u985e\u4f3c\u65bc\u9470\u5319\u8207\u9396\u7684\u7d50\u5408\u65b9\u5f0f\uff0c\u5927\u9ebb\u7d20\u6703\u8207\u9ad4\u5167\u7684\u5927\u9ebb\u7d20\u53d7\u9ad4\u7db2\u8def\u9032\u884c\u7279\u7570\u6027\u7d50\u5408\uff0c\u5f9e\u800c\u4fdd\u6301\u5167\u7a69\u614b\u7684\u7a69\u5b9a\u6027\u3002\u4eba\u9ad4\u4e2d\u6700\u4e3b\u8981\u7684\u5169\u7a2e\u5927\u9ebb\u7d20\u53d7\u9ad4\u662fCB1\u548cCB2\u3002\u524d\u8005\u4e3b\u8981\u5b58\u5728\u65bc\u5927\u8166\u548c\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u4e2d\uff1b\u5f8c\u8005\u5247\u4e3b\u8981\u5b58\u5728\u4e8e\u5468\u570d\u5668\u5b98\u4e2d\uff0c\u5c24\u5176\u662f\u514d\u75ab\u7cfb\u7d71\u7684\u7d30\u80de\u4e2d\u3002CB2-skin\u2122 \u4f5c\u70ba CBD\uff08\u5927\u9ebb\u4e8c\u915a\uff09\u884d\u751f\u7269\u7684\u6709\u6548\u66ff\u4ee3\u7269\uff0c\u53ef\u4ee5\u7279\u7570\u6027\u5730\u555f\u52d5\u76ae\u819a\u7d44\u7e54\u4e2d\u7684CB2\u53d7\u9ad4\uff0c\u5be6\u73fe\u5167\u7a69\u614b\u7684\u4fdd\u6301\uff0c\u4e26\u8212\u7de9\u3001\u653e\u9b06\u808c\u819a\uff0c\u6e1b\u5c11TRPV1\u5f15\u8d77\u7684\u808c\u819a\u4e0d\u9069\uff0c\u4ee4\u808c\u819a\u66f4\u52a0\u8212\u9069\u3002<\/p>\n

    \n
  1. CB2-skin\u2122\u5c0dCB2\u53d7\u9ad4\u7684\u555f\u52d5\u5be6\u9a57<\/li>\n<\/ol>\n

    \u5be6\u9a57\u7269\u4ef6\uff1a\u4f86\u81ea\u65bc38\u6b72\u5973\u6027\u6350\u8d08\u8005\u7684\u6d3b\u9ad4\u76ae\u819a\u7d44\u7e54\u5207\u7247\uff1b<\/p>\n

    \u61c9\u7528\uff1a\u5b89\u6170\u5291\u30010.3%\u62161%\u7684CB2-skinTM\u88fd\u5291\uff082x\/d\uff0948\u5c0f\u6642\uff1b<\/p>\n

    \u8a55\u4f30\u65b9\u5f0f\uff1aCB2\u514d\u75ab\u67d3\u8272\uff08\u7da0\u8272\u87a2\u5149\uff0cx40\uff09\uff1b<\/p>\n

    \u7d50\u8ad6\uff1a\u7531\u57162\u53ef\u4ee5\u660e\u986f\u767c\u73fe\uff0c\u96e2\u9ad4\u76ae\u819a\u7d44\u7e54\u5728\u61c9\u7528\u4e86CB2-skin\u2122 \u5f8c\uff0cCB2\u53d7\u9ad4\u7684\u8868\u9054\u5f97\u5230\u4e86\u986f\u8457\u7684\u63d0\u5347\u3002<\/p>\n

    \"\"<\/p>\n

    \u57162- CB2-skin\u2122\u5c0dCB2\u53d7\u9ad4\u7684\u555f\u52d5\u5be6\u9a57<\/p>\n

      \n
    1. CB2-skin\u2122\u6539\u5584\u76ae\u819a\u5167\u7a69\u614b<\/li>\n<\/ol>\n

      \u5be6\u9a57\u7269\u4ef6\uff1a\u4f86\u81ea\u65bc36\u6b72\u5973\u6027\u6350\u8d08\u9ad4\u7684NHK\uff08\u6b63\u5e38\u4eba\u89d2\u8cea\u7d30\u80de\uff09\uff1b<\/p>\n

      \u61c9\u7528\uff1a0.001% CB2-skin\u2122\uff0c1\u00b5M CB2 \u5927\u9ebb\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291 AM1241\uff0c1\u00b5M CB2 \u5927\u9ebb\u7d20\u53d7\u9ad4\u62ee\u6297\u5291 AM630\u00a0 (1x\/d)\u00a0 24\u5c0f\u6642\uff1b<\/p>\n

      \u8a55\u4f30\u65b9\u5f0f\uff1aCB2\u86cb\u767d\u5370\u8de1\uff1b<\/p>\n

      \u7d50\u8ad6\uff1a\u7531\u65bcCB2\u62ee\u6297\u5291\u53ef\u4ee5\u963b\u6b62CB2-skin\u2122 \u5c0dCB2\u53d7\u9ad4\u7684\u6b63\u56de\u994b\u8abf\u7bc0\u3002\u53ef\u898b\uff0cCB2-skin\u2122 \u5c0d\u65bcCB2\u53d7\u9ad4\u7684\u555f\u52d5\u662f\u5177\u6709\u7279\u7570\u6027\u7684\u3002<\/p>\n

      \"\"<\/p>\n

      \u57163- CB2-skin\u2122\u5c0dCB2\u53d7\u9ad4\u7684\u7279\u7570\u6027\u9a57\u8b49\u5be6\u9a57<\/p>\n

      \u8212\u7de9\u654f\u611f\uff0c\u89e3\u6182\u201c\u6291\u9b31\u808c\u201d<\/p>\n

      TRPV1\u662f\u4e00\u7a2e\u7531\u71b1\u6216\u8fa3\u6912\u7d20\u555f\u52d5\u7684\u71b1\u654f\u53d7\u9ad4\uff0c\u4f5c\u70ba\u76ae\u819a\u4e0d\u9069\u7684\u4e00\u500b\u91cd\u8981\u6a19\u8a8c\uff0c\u5728\u7d93\u53d7\u7d2b\u5916\u7dda\u7167\u5c04\u548c\u8001\u5316\u7684\u808c\u819a\u4e2d\u6703\u986f\u8457\u589e\u52a0\uff0c\u4e26\u8207\u76ae\u819a\u548c\u982d\u76ae\u7684\u767c\u7662\u751a\u81f3\u7279\u61c9\u6027\u76ae\u708e\u548c\u904e\u654f\u6027\u3001\u63a5\u89f8\u6027\u76ae\u708e\u9ad8\u5ea6\u76f8\u95dc\u3002\u800c\u901a\u904e\u555f\u52d5CB2\u53d7\u9ad4\uff0c\u5247\u6703\u91cb\u653e\u51fa\u03b2-\u5167\u5561\u80bd\u6e1b\u5c11TRPV1\u8a98\u5c0e\u7522\u751f\u7684\u76ae\u819a\u75db\u89ba\u7b49\u4e0d\u9069\u611f\u53d7\u767c\u751f\u7684\u53ef\u80fd\u6027\u3002<\/p>\n

      CB2-skin\u2122\u4fc3\u9032\u76ae\u819a\u91cb\u653e\u03b2-\u5167\u5561\u80bd<\/p>\n

      \u5be6\u9a57\u7269\u4ef6\uff1a\u4f86\u81ea38\u6b72\u5973\u6027\u4f9b\u9ad4\u7684\u96e2\u9ad4\u76ae\u819a\u7d44\u7e54\uff1b<\/p>\n

      \u61c9\u7528\uff1a0.3%\u548c1% CB2-skin\u2122 (2x\/d)\u00a0 48h\u2019\u8a55\u4f30\uff1a\u03b2-\u5167\u5561\u80bd\u514d\u75ab\u67d3\u8272(\u7da0\u8272;x20)\uff1b<\/p>\n

      \u7d50\u8ad6\uff1a\u7531\u4ee5\u4e0a\u5be6\u9a57\u53ef\u4ee5\u770b\u51fa\uff0cCB2-skin\u2122 \u8207\u76ae\u819a\u4e2d\u03b2-\u5167\u5561\u80bd\u542b\u91cf\u7684\u660e\u986f\u589e\u52a0\u6709\u95dc\u3002<\/p>\n

      \"\"<\/p>\n

      \u57165- CB2-Skin\u2122 \u4fc3\u9032\u03b2-\u5167\u5561\u80bd\u542b\u91cf\u5be6\u9a57<\/p>\n

        \n
      1. CB2-skin\u2122 \u6539\u5584\u76ae\u819a\u7684\u654f\u611f\u523a\u75db<\/li>\n<\/ol>\n

        \u5be6\u9a57\u7269\u4ef6\uff1a26\u540d\u76ae\u819a\u654f\u611f\u7684\u767d\u7a2e\u4eba\u53d7\u8a66\u8005\uff1b<\/p>\n

        \u7522\u54c1\u61c9\u7528\uff1a\u4f7f\u7528\u5b89\u6170\u5291\u4e73\u6db2\u6216\u542b 1% CB2-skin\u2122\u4e73\u6db2 28 \u5929\uff1b<\/p>\n

        \u640d\u50b7\uff1a\u61c9\u7528\u542b\u67090.01%\u8fa3\u6912\u7d20\u768410%\u4e59\u9187\u65bc\u4e00\u5074\u7684\u9f3b\u5507\u6e9d\uff0c10%\u4e59\u9187\u65bc\u53e6\u4e00\u5074\uff0c\u6301\u7e8c 30s\uff1b<\/p>\n

        \u8a55\u4f30\u65b9\u5f0f\uff1a\u572810\u5206\u9418\u5167\u6bcf\u5206\u9418\u8a55\u4f30\u4e00\u6b21\u523a\u75db\u611f\uff0c\u4ee50 – 4\u70ba\u9593\u9694\uff0c\u7136\u5f8c\u9032\u884c\u8a55\u5206\uff1b<\/p>\n

        \u7d50\u8ad6\uff1a\u5fd7\u9858\u8005\u5728\u4f7f\u7528\u542b\u67091%\u7684CB2-skin\u2122 \u7684\u4e73\u6db228\u5929\u540e\uff0c\u76ae\u819a\u523a\u75db\u611f\u660e\u986f\u4e0b\u964d\uff0c\u76f8\u5c0d\u4f7f\u7528\u5b89\u6170\u5291\u4e73\u6db2\u7d44\uff0c\u6539\u5584\u4e86\u76ae\u819a\u654f\u611f\u3002<\/p>\n

        \"\"<\/p>\n

        \u57166- CB2-Skin\u2122\u6539\u5584\u76ae\u819a\u654f\u611f\u5be6\u9a57<\/p>\n

        \u63d0\u5347\u76ae\u819a\u5167\u7a69\u614b\uff0c\u5e36\u4f86\u66f4\u52a0\u5065\u5eb7\u3001\u5e74\u8f15\u548c\u5f48\u6f64\u7684\u808c\u819a<\/p>\n

        CB2-skin\u2122\u6e1b\u7de9\u76ae\u819a\u8870\u8001<\/p>\n

        CB2-skin\u2122 \u53ef\u4ee5\u589e\u52a0\u771f\u76ae\u81a0\u539f\u86cb\u767d\uff0c\u589e\u52a0\u771f\u76ae\u5bc6\u5ea6\uff0c\u63d0\u5347\u808c\u819a\u4e2d\u7684\u81a0\u539f\u86cb\u767d\u548c\u515c\u7532\u86cb\u767d\u7684\u5408\u6210\uff0c\u5f9e\u800c\u8d77\u5230\u6de1\u5316\u9762\u90e8\u7684\u7d30\u7d0b\uff0c\u63d0\u5347\u9762\u90e8\u8f2a\u5ed3\u7dda\u689d\u548c\u5e73\u6ed1\u808c\u819a\u7d0b\u7406\u7684\u6548\u679c\uff0c\u5ef6\u7de9\u808c\u819a\u8870\u8001\uff0c\u6539\u5584\u76ae\u819a\u5916\u5728\u7684\u72c0\u614b\u3002<\/p>\n

        \"\"<\/p>\n

        \u57167-CB2-skin\u2122 \u589e\u52a0\u771f\u76ae\u5bc6\u5ea6\u5be6\u9a57\u7d50\u679c<\/p>\n

        \"\"<\/p>\n

        \u57168-CB2-skin\u2122 \u6de1\u5316\u7d30\u7d0b\u63d0\u5347\u8f2a\u5ed3\u5be6\u9a57\u7d50\u679c<\/p>\n

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         <\/p>\n

        \u2122 \u4e9e\u4ec0\u862d\u6216\u5176\u5b50\u516c\u53f8\u7684\u5546\u6a19<\/p>\n

         <\/p>\n

        \u53c3\u8003\u6587\u737b\uff1a<\/strong><\/p>\n

        [1] Legat FJ,Armstrong CA,Ansel JC.The cutaneous neurosensory system in skin disease[J]. Adv Dermatol,2002,18:91-109.<\/p>\n

        [2] \u9f94\u77f3\u7b49\uff0c\u795e\u7d93\u4ecb\u8cea\u8207\u76ae\u819a\u7f8e\u5bb9\u95dc\u4fc2\u7684\u7814\u7a76\u9032\u5c55[J].\u4e2d\u570b\u7f8e\u5bb9\u91ab\u5b78, 2011,5: 861-862<\/p>\n

         <\/p>\n","protected":false},"excerpt":{"rendered":"

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