{"id":209,"date":"2021-08-16T15:01:11","date_gmt":"2021-08-16T07:01:11","guid":{"rendered":"https:\/\/taiwancosmetic.org\/?p=209"},"modified":"2021-08-16T15:01:11","modified_gmt":"2021-08-16T07:01:11","slug":"sytenol-a-retinol%e6%8a%97%e8%a1%b0%e8%80%81%e7%9a%84%e7%ac%ac%e2%bc%80%e5%80%8b%e5%a4%a9%e7%84%b6%e6%9b%bf%e4%bb%a3%e5%93%81","status":"publish","type":"post","link":"https:\/\/taiwancosmetic.org\/?p=209","title":{"rendered":"Sytenol\u00ae A&#8211;Retinol\u6297\u8870\u8001\u7684\u7b2c\u2f00\u500b\u5929\u7136\u66ff\u4ee3\u54c1"},"content":{"rendered":"<p>\u6295\u7a3f\u6587\u7ae0\uff0c\u4f5c\u8005\uff1a\u53f0\u7063\u5927\u660c\u83ef\u5609\u80a1\u4efd\u6709\u9650\u516c\u53f8\u3002<\/p>\n<p><strong>Sytenol\u00ae A<\/strong><\/p>\n<p><strong>\u00a0<\/strong>\u5f9e2018\u5e74\u958b\u59cbBakuchiol\u958b\u59cb\u88ab\u5927\u91cf\u7684\u641c\u5c0b\u3002Mintel\u5c07Bakuchiol\u5217\u70ba2019\u5e74\u53ca\u4ee5\u5f8c\u7684\u4e3b\u8981\u8da8\u52e2\u3002Bakuchiol (Sytenol\u00ae A)\u5728\u6700\u8fd1\u300a\u82f1\u570b\u76ae\u819a\u79d1\u5b78\u300b\u96dc\u8a8c\u4e0a\u767c\u8868\u7684\u4e00\u9805\u7814\u7a76\u8868\u660e\uff0cBakuchiol (Sytenol\u00ae A)\u6bd4\u8d77A\u9187\u66f4\u5177\u6709\u76ca\u8655\uff0c\u4e26\u4e14\u5177\u6709\u66f4\u597d\u7684\u76ae\u819a\u8010\u53d7\u6027\u3002<\/p>\n<p>\u96a8\u8457\u5e74\u9f61\u7684\u589e\u2ed1\uff0c\u2f6a\u819a\u6703\u5931\u53bb\u5f48\u6027\uff0c\u8b8a\u8584\u3001\u8b8a\u5f31\uff0c\u5bb9\u6613\u51fa\u73fe\u76ba\u7d0b\u548c\u2f8a\u7d20\u6c89\u8457\u904e\u5ea6\u3002\u5982\u4f55\u9632\u2f4c\u9019\u7a2e\u60c5\u6cc1\u767c\u2f63\uff1f\u9019 \u6297\u8870\u8001\u7522\u54c1\u7684\u4e3b\u8981\u2f6c\u6a19\u662f\u6e1b\u5c11\u4e26\u6700\u7d42\u6d88\u9664\u7d30\u7d0b\u548c\u76ba\u7d0b\u7684\u51fa\u73fe\uff0c\u4e26\u63d0\u4f9b\u5747\u52fb\u7684\u819a\u2f8a \u6548\u679c\u3002\u5be6\u73fe\u9019\u2f00\u2f6c\u6a19\u7684\u2f45\u6cd5\u662f\u2fb8\u5148\u9632\u2f4c\u76ba\u7d0b\u5f62\u6210\u3002\u9019\u610f\u5473\u8457\u9632\u2f4c\u2f6a\u819a\u9032\u2f00\u6b65\u53d7\u640d\uff0c\u4e3b\u8981\u6062\u5fa9\u7d30\u80de\u5916\u57fa\u8cea (ECM)\u3001\u771f\u2f6a-\u8868\u2f6a\u9023\u63a5 (DEJ) \u5340\u57df\u4e26\u4fdd\u6301\u2f6a\u819a\u2f54\u5206\u3002<!--more--><\/p>\n<h3>\u7522\u54c1\u4fe1\u606f<\/h3>\n<p><strong><span style=\"color: #0000ff;\">\u5546\u54c1\u540d\u7a31\u00a0<\/span>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 <\/strong><strong>Sytenol\u00ae A<\/strong><\/p>\n<p><span style=\"color: #0000ff;\"><strong>INCI<\/strong><\/span><strong><span style=\"color: #0000ff;\">\u540d\u7a31\u00a0<\/span> \u00a0 \u00a0 \u00a0 \u00a0 \u00a0<\/strong>\u88dc\u9aa8\u8102\u915a<\/p>\n<p><strong><span style=\"color: #0000ff;\">\u5316\u5b78\u540d\u7a31\u00a0 \u00a0<\/span> \u00a0 \u00a0 \u00a0 <\/strong>Phenol, 4-[(1E, 3S)-3-ethenyl-3, 7-dimethyl-1, 6-octadienyl]<\/p>\n<p><span style=\"color: #0000ff;\"><strong>CAS#<\/strong>\u00a0 \u00a0<\/span> \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a010309-37-2<\/p>\n<p><span style=\"color: #0000ff;\"><strong>EC<\/strong><strong>#<\/strong>\u00a0<\/span> \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0685-515-9<\/p>\n<p><strong><span style=\"color: #0000ff;\">Origin\u00a0 \u00a0<\/span> \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0<\/strong>100% \u5929\u7136\uff1b\u5f9e\u53ef\u98df\u2f64\u7684\u7a2e\u2f26\u4e2d\u63d0\u53d6\u548c\u7d14\u5316<\/p>\n<p><strong><span style=\"color: #0000ff;\">\u5916\u89c0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/span>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/strong>\u9ec3\u2f8a\u2f84\u9ec3\u68d5\u2f8a\u6db2\u9ad4<\/p>\n<p><strong><span style=\"color: #0000ff;\">\u7d14\u5ea6\u00a0<\/span> \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 <\/strong>\u6700\u4f4e 98%\uff08\u901a\u5e38 &gt;99%\uff09<\/p>\n<p><span style=\"color: #0000ff;\"><strong>\u6eb6\u89e3\u6027<\/strong><strong>\/<\/strong><\/span><strong><span style=\"color: #0000ff;\">\u6df7\u6eb6\u6027\u00a0<\/span> \u00a0 \u00a0 \u00a0<\/strong>\u53ef\u8207\u591a\u7a2e\u758f\u2f54\u6027\u6f64\u819a\u5291\u6df7\u6eb6<\/p>\n<p><strong><span style=\"color: #0000ff;\">\u7a69\u5b9a\u00a0<\/span>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 <\/strong>\u5149\u5316\u5b78\u548c\u2f54\u89e3\u7a69\u5b9a<\/p>\n<p><strong><span style=\"color: #0000ff;\">\u5efa\u8b70\u4f7f\u2f64\u91cf\u00a0 \u00a0<\/span> \u00a0 \u00a0 \u00a0 \u00a0 <\/strong>0.5 \u2f84 1%<\/p>\n<p><strong><span style=\"color: #0000ff;\">\u8caf\u5b58\u74b0\u5883\u00a0 \u00a0<\/span> \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 <\/strong>\u5728 +10 \u2f84 +30 0 C \u4e0b\u5132\u5b58\u5728\u539f\u59cb\u5bc6\u5c01\u5bb9\u5668\u4e2d\uff1b\u907f\u514d\u66b4\u9732\u65bc\u5149\u548c\u71b1<\/p>\n<p><strong><span style=\"color: #0000ff;\">\u6cd5\u898f\u00a0<\/span> \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 <\/strong>\u7372\u51c6\u5728\u6240\u6709\u4e3b\u8981\u570b\u5bb6\/\u5730\u5340\u4f7f\u2f64\u2014\u2014\u7f8e\u570b\u3001\u6b50\u6d32\u3001\u6fb3\u2f24\u5229\u4e9e\u3001\u52a0\u62ff\u2f24\u3001<\/p>\n<p>\u2f47\u672c\u3001\u97d3\u570b\u548c\u8a31\u591a\u5176\u4ed6\u570b\u5bb6<\/p>\n<p><strong><span style=\"color: #0000ff;\">\u5c08\u5229\u00a0 \u00a0 \u00a0<\/span> \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 <\/strong>US 8,529,967; US 8,859,021\uff1b\u591a\u9805\u6b63\u5728\u7533\u8acb\u7684\u7f8e\u570b\u548c\u6b50\u6d32\u5c08\u5229<\/p>\n<h1>Sytenol\u00ae A &#8211; Retinol\u7684\u529f\u80fd\u985e\u4f3c\u7269<\/h1>\n<p>\u5f9e\u706b\u5c71\u5716\u7684\u5404\u7a2eDNA\u53cd\u61c9\u89d2\u5ea6\u4f86\u770b\uff0cSytenol\u00ae A\u5b89\u5168\u5730\u6a21\u64ecRetinol\u7684\u7279\u6027\uff0c\u4e26\u4e14\u6c92\u6709Retinol\u7684\u8ca0\u9762\u5f71\u97ff\uff08Fisher et al., FASEB J,1002-1013, 1996\uff09\uff0c\u7531\u6b64\u53ef\u898b\uff0cSytenol\u00ae A\u662f\u4e00\u500b\u975e\u5e38\u53d7\u8ffd\u6367\u7684\u6210\u5206\u3002\u706b\u5c71\u5716\u8aaa\u660e\u4e86\u4f7f\u7528\u91cd\u5efa\u7684\u8868\u76ae\u7d30\u80de\u9032\u884c\u7684 DNA \u5fae\u9663\u5217\u5be6\u9a57\u4e2d\uff0cRetinol\u548c Sytenol\u00ae A \u7684\u5206\u5b50\u7279\u5fb5\u3002\u9019\u986f\u793a\u4e86\u975e\u5e38\u76f8\u4f3c\u7684\u6574\u9ad4\u5f62\u72c0\uff0c\u8868\u660e\u76ae\u819a\u66ff\u4ee3\u6a21\u578b\u4e2d\u57fa\u56e0\u8868\u9054\u7684\u6574\u9ad4\u8abf\u88fd\u76f8\u4f3c\u3002\u591a\u9805\u6bd4\u8f03\u7814\u7a76\u8868\u660e\uff0cSytenol\u00ae A \u662fRetinol\u7684\u771f\u6b63\u66ff\u4ee3\u54c1\uff08Chaudhuri, In Cosmeceuticals and Active Cosmetics, 3r Edition, Eds., Maibach et al., Chapter 1, 1-18, 2015\uff09\uff0c\u7528\u65bc\u6297\u8870\u8001\u61c9\u7528\u4e26\u4e14\u78ba\u5be6\u6c92\u6709Retinol\u65e2\u6709\u7684\u4e0d\u5b89\u5168\u6027\u548c\u7a69\u5b9a\u6027\u554f\u984c\u3002\u6700\u8fd1\u7531\u52a0\u5dde\u5927\u5b78\u6234\u7dad\u65af\u5206\u6821\u76ae\u819a\u79d1\u91ab\u751f\u5728 Sytenol\u00ae A \u548cRetinol\u4e4b\u9593\u9032\u884c\u7684\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u81e8\u5e8a\u7814\u7a76\u8868\u660e\uff0c\u9019\u5169\u7a2e\u5316\u5408\u7269\u986f\u8457\u6e1b\u5c11\u4e86\u76ba\u7d0b\u8868\u9762\u7a4d\u548c\u8272\u7d20\u6c89\u8457\u904e\u5ea6\uff0c\u5316\u5408\u7269\u4e4b\u9593\u6c92\u6709\u7d71\u8a08\u5b78\u5dee\u7570\u3002Retinol\u53d7\u8a66\u8005\u7522\u751f\u66f4\u591a\u7684\u9762\u90e8\u76ae\u819a\u76ae\u5c51\u3001\u707c\u71b1\u611f\u548c\u523a\u75db\u3002\u4f5c\u8005\u5f97\u51fa\u7d50\u8ad6\uff0cSytenol\u00ae A \u662f\u4e00\u7a2e\u6bd4Retinol\u66f4\u5177\u6709\u8010\u53d7\u6027\u7684\u66ff\u4ee3\u54c1\u3002<\/p>\n<p><span style=\"font-size: 10pt;\">\uff08Dhaliwal et al, British J Dermatology, 2018 Jun 27. doi: 10.1111\/bjd.16918\uff09\u3002<\/span><\/p>\n<p><strong>DNA <\/strong><strong>\u5fae\u9663\u5217\u6578\u64da\u7684\u706b\u2f2d\u5716\uff1aRetinol\u8207 <\/strong><strong>Sytenol\u00aeA<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-212 size-full\" src=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u706b\u5c71\u5716-e1628864600980.jpg\" alt=\"\" width=\"640\" height=\"209\" srcset=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u706b\u5c71\u5716-e1628864600980.jpg 640w, https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u706b\u5c71\u5716-e1628864600980-400x131.jpg 400w\" sizes=\"auto, (max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 984px) 61vw, (max-width: 1362px) 45vw, 600px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u81e8\u5e8a\u8b49\u660e\u53ef\u6e1b\u5c11\u591a\u7a2e\u8870\u8001\u8de1\u8c61<\/strong><\/p>\n<h3>\u6297\u76ba\u9000\u7d05\u6e2c\u8a66\uff1a<\/h3>\n<ul>\n<li><strong>\u53d7\u8a66\u8005 <\/strong><strong>\u2013 <\/strong>17\u4eba\uff1b16\u4eba \u5df2\u5b8c\u6210\u3002<\/li>\n<li><strong>\u5e74\u9f61<\/strong> \u2013 41 \u2f84 60 \u6b72\uff1b\u2f69\u7a2e\u2f08 (14),\u2ec4\u73ed\u7259\u88d4 (2)\u3002<\/li>\n<li><strong>\u6e2c\u8a66\u6642\u9593 <\/strong><strong>\u2013 <\/strong>12 \u9031\u3002<\/li>\n<li><strong>\u6e2c\u8a66\u9ede<\/strong><strong>\u2014\u2014<\/strong>\u5168\u81c9\u3002<\/li>\n<li><strong>\u6e2c\u8a66\u7269\u8cea <\/strong><strong>\u2013<\/strong>\u542b\u6709 0.5% Sytenol\u00aeA\u7684\u4e73\u6db2\uff1b\u4e0d\u542b\u9632\u66ec\u971c\u548c\u4fdd\u6fd5\u5291\u3002<\/li>\n<li><strong>\u61c9\u2f64\u983b\u7387 <\/strong><strong>\u2013<\/strong>\u6bcf\u5929\u5169\u6b21\u7d04 2 \u514b\u3002<\/li>\n<li><strong>\u2f45\u6cd5\u8ad6 <\/strong><strong>\u2013<\/strong>\u5c08\u5bb6\u8a55\u5206\/\u2f29\u7d44\u6210\u54e1\u7684\u2f83\u6211\u8a55\u4f30\uff08\u8a55\u5206 0 \u2f844\uff09\uff1a<\/li>\n<\/ul>\n<p>\uff081\uff09\u7c97\u7cd9\u5ea6\u548c\u4e7e\u71e5\u5ea6\uff1b(2) \u7d30\u7d0b\u548c\u76ba\u7d0b\uff1b(3) \u819a\u2f8a\uff1b(4)\u2f6a\u819a\u5f48\u6027\u548c\u7dca\u7dfb\u5ea6\uff1b(5) \u5149\u8f1d\uff1b(6) \u589e\u4eae\uff1b(7) \u6574\u9ad4\u773c\u90e8\u5340\u57df \u5916\u8c8c; \u77fd\u81a0\u4eff\u54c1\u5206\u6790\uff1a\u76ba\u7d0b\u6df1\u5ea6\u548c\u2f6a\u819a\u7c97\u7cd9\u5ea6\uff1b \u651d\u5f71\uff1a\u6cbb\u7642\u524d\u5f8c\uff1b\u8b80\u6578\u53d6\u2f83\u57fa\u7dda\uff0c\u7b2c4\u30018 \u548c 12 \u9031\u8b80\u53d6\u6578\u503c\u3002<\/p>\n<ul>\n<li><strong>\u7d71\u8a08\u5206\u6790 <\/strong><strong>\u2013<\/strong>\u7d71\u8a08\u986f\u8457\u6027\u5b9a\u7fa9\u70ba p \u22640.05\u3002<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-214 size-full\" src=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u6cbb\u7642\u5716-e1628864578592.jpg\" alt=\"\" width=\"640\" height=\"639\" srcset=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u6cbb\u7642\u5716-e1628864578592.jpg 640w, https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u6cbb\u7642\u5716-e1628864578592-250x250.jpg 250w, https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u6cbb\u7642\u5716-e1628864578592-100x100.jpg 100w, https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u6cbb\u7642\u5716-e1628864578592-400x399.jpg 400w\" sizes=\"auto, (max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 984px) 61vw, (max-width: 1362px) 45vw, 600px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-215 size-full\" src=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u7c97\u9020\u76ae\u819a\u6539\u5584\u5716-e1628864561195.jpg\" alt=\"\" width=\"640\" height=\"479\" srcset=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u7c97\u9020\u76ae\u819a\u6539\u5584\u5716-e1628864561195.jpg 640w, https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u7c97\u9020\u76ae\u819a\u6539\u5584\u5716-e1628864561195-400x299.jpg 400w\" sizes=\"auto, (max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 984px) 61vw, (max-width: 1362px) 45vw, 600px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-216 size-full\" src=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u5c08\u5bb6\u8a55\u4f30\u5716-e1628864541999.jpg\" alt=\"\" width=\"640\" height=\"507\" srcset=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u5c08\u5bb6\u8a55\u4f30\u5716-e1628864541999.jpg 640w, https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u5c08\u5bb6\u8a55\u4f30\u5716-e1628864541999-400x317.jpg 400w\" sizes=\"auto, (max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 984px) 61vw, (max-width: 1362px) 45vw, 600px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-217 size-full\" src=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u6d88\u8cbb\u8005\u81ea\u6211\u8a55\u4f30-e1628864526321.jpg\" alt=\"\" width=\"637\" height=\"546\" srcset=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u6d88\u8cbb\u8005\u81ea\u6211\u8a55\u4f30-e1628864526321.jpg 637w, https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u6d88\u8cbb\u8005\u81ea\u6211\u8a55\u4f30-e1628864526321-400x343.jpg 400w\" sizes=\"auto, (max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 984px) 61vw, (max-width: 1362px) 45vw, 600px\" \/><\/p>\n<h3><span style=\"color: #993300;\">\u7d50\u679c<\/span><\/h3>\n<p>\u7d50\u679c\u6e05\u695a\u5730\u8868\u660e\uff0c\u5728\u6cbb\u7642\u5341\u4e8c\u9031\u5f8c\uff0c\u89c0\u5bdf\u5230\u7d30\u7d0b\u548c\u76ba\u7d0b\u3001\u8272\u7d20\u6c89\u8457\u3001\u5f48\u6027\u3001\u7dca\u7dfb\u5ea6\u548c\u6574\u9ad4\u5149\u640d\u50b7\u7684\u986f\u8457\u6539\u5584\uff0c\u5c0d\u76ae\u819a\u6c92\u6709\u523a\u6fc0\u4f5c\u7528\u3002\u57fa\u65bc\u5c0dRetinol\u548c Sytenol\u00ae A \u7684\u6bd4\u8f03\u7814\u7a76\uff0c\u6211\u5011\u5f97\u51fa\u7d50\u8ad6\uff0cSytenol\u00ae A \u662f\u7b2c\u4e00\u500b\u771f\u6b63\u53ef\u4ee5\u53d6\u4ee3Retinol\u7684\u6297\u8870\u8001\u7522\u54c1(Chaudhuri &amp; Bojanowski, Intern J Cosmet Sci, 36(3):221-230, 2014)\u3002<\/p>\n<h2><strong>\u7522\u54c1\u80cc\u5f8c\u7684\u79d1\u5b78<\/strong><strong>\u2014<\/strong><strong>\u4fee\u5fa9\u6027\u6297\u8870\u8001<\/strong><\/h2>\n<h3>\u6bd4\u8f03\u81a0\u539f\u523a\u6fc0\u4f5c\u2f64<\/h3>\n<p>\u5728\u8001\u5316\u7684\u2f6a\u819a\u4e2d\uff0c\u584c\u9677\u7684\u6210\u7e96\u7dad\u7d30\u80de\u7522\u2f63\u4f4e\u2f54\u5e73\u7684\u81a0\u539f\u86cb\u2f69\u548c\u2fbc\u2f54\u5e73\u7684\u81a0\u539f\u86cb\u2f69\u964d\u89e3\u9176\u3002\u9019\u7a2e\u4e0d\u5e73\u8861\u9032\u2f00\u6b65\u767c\u5c55 \u5728\u2f00\u500b\u2f83\u6211\u5ef6\u7e8c\u7684\u3001\u6c38\u7121\u2f4c\u5883\u7684\u6709\u5bb3\u5faa\u74b0\u4e2d\u7684\u8870\u8001\u904e\u7a0b\u3002\u8af8\u5982\u5c40\u90e8Retinol\u6216A\u9178\u4e4b\u985e\u7684\u6cbb\u7642\u5df2\u88ab \u81e8\u5e8a\u8b49\u660e\u53ef\u523a\u6fc0\u65b0\u7684\u3001\u672a\u53d7\u640d\u7684\u81a0\u539f\u86cb\u2f69\u7684\u7522\u2f63\uff08<em>Fisher et al., Arch Dermatol, 144(5):666-672, 2008<\/em>\uff09\u3002\u9644\u4ef6 \u6210\u7e96\u7dad\u7d30\u80de\u5c0d\u9019\u7a2e\u65b0\u7684\u81a0\u539f\u86cb\u2f69\u7522\u2f63\u5f48\u6027\uff0c\u9019\u53cd\u904e\u4f86\u2f1c\u5e73\u8861\u4e86\u81a0\u539f\u86cb\u2f69\u7684\u7522\u2f63\u548c\u964d\u89e3\uff0c\u5f9e\u2f7d\u6e1b\u7de9\uff0c\u5982\u679c\u4e0d\u662f \u9006\u8f49\uff0c\u8001\u5316\u904e\u7a0b\u3002\u6211\u5011\u5df2\u7d93\u901a\u904e ELISA \u548c\u7d44\u7e54\u5316\u5b78\u2f45\u6cd5\u6e2c\u91cf\u4e86\u81a0\u539f\u86cb\u2f69\u523a\u6fc0\u3002ELISA \u8a55\u4f30\u63a1\u2f64\u4f86\u2f83\u65b0\u2f63\u5152\uff08I \u578b\u548c IV \u578b\u81a0\u539f\u86cb\u2f69\uff09\u6216\u6210\u719f\uff08III \u578b\u81a0\u539f\u86cb\u2f69\uff09\u6210\u7e96\u7dad\u7d30\u80de\u7684\u7d30\u80de\u57f9\u990a\u689d\u4ef6\u57f9\u990a\u57fa ( <em>Chaudhuri &amp; Bojanowski, Intern J Cosmet Sci, 36(3):221-230, 2014 <\/em>)\u3002\u8a72\u767c\u73fe\u7684\u7d50\u679c\uff0c\u7e3d\u7d50\u5728\u4e0b\u8868\u4e2d\uff08%\u523a\u6fc0\u8207\u5c0d\u7167\uff09\uff0c \u8b49\u660e\u8207Retinol\u76f8\u6bd4\uff0cSytenol \u00ae A\u5c0d\u81a0\u539f\u86cb\u2f69\u7684\u523a\u6fc0\u6709\u986f\u8457\u6539\u5584\uff0c\u56e0\u6b64\u9810\u671f\u5177\u6709\u66f4\u2f24\u7684\u4fee\u5fa9\u6548\u679c\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-218 size-full\" src=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u6bd4\u8f03\u81a0\u539f-e1628864508532.jpg\" alt=\"\" width=\"640\" height=\"103\" srcset=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u6bd4\u8f03\u81a0\u539f-e1628864508532.jpg 640w, https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u6bd4\u8f03\u81a0\u539f-e1628864508532-400x64.jpg 400w\" sizes=\"auto, (max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 984px) 61vw, (max-width: 1362px) 45vw, 600px\" \/><\/p>\n<h3>\u95dc\u9375\u6297\u8870\u8001\u57fa\u56e0\u7684\u8abf\u7bc0<\/h3>\n<p>Sytenol \u00ae A \u548cRetinol\u5c0d\u7279\u5b9a\u907a\u50b3\u9014\u5f91\u7684\u5f71\u97ff\uff08\u4f86\u2f83 Mattek \u7684\u5168\u539a\u5ea6\u8868\u2f6a\u7d44\u7e54\uff0c\u500d\u6578\u8b8a\u5316 \u00b1 &gt; 2\uff1bp \u2264 0.05\uff09\u8207Retinol\u529f\u80fd\u76f8\u95dc\u7684\u6bd4\u8f03\u3002\u2fb8\u5148\uff0c\u8a31\u591a\uff08\u4f46\u4e0d\u662f\u5168\u90e8\uff09\u57fa\u56e0\u7684\u985e\u4f3c\u8abf\u7bc0\u2f64\u65bc\u985eRetinol\u7d50\u5408\u548c \u89c0\u5bdf\u5230\u4ee3\u8b1d\u57fa\u56e0\u3002\u7c21\u8981\u4ecb\u7d39\u4e86\u9019\u4e9b\u57fa\u56e0\u4ee5\u53caRetinol\u548c Sytenol \u00ae A \u5c0d\u6bcf\u500b\u57fa\u56e0\u7684\u5f71\u97ff \u4ee5\u4e0b\u3002\u540c\u6a23\uff0c\u8a31\u591a\u57fa\u56e0\u53c3\u8207\u7d30\u80de\u5916\u57fa\u8cea (ECM) \u548c\u771f\u2f6a\u8868\u2f6a\u7684\u7522\u2f63\u548c\u7dad\u6301\u3002<\/p>\n<p>\u7d50\uff08DEJ\uff09\u500b\u5340\u57df\u662f\u7531\u5169\u500bRetinol\u548cSytenol\u8abf\u88fd\u00ae A\uff08\uff1a<em>221-230<\/em>\uff0c<em>2014<\/em>\u55ac\u8d6b\u2fa5\uff06<em>Bojanowski<\/em>\uff0c\u5be6\u7fd2\u2f63<em>\u0134Cosmet<\/em>\u79d1\u5b78\uff0c<em>36<\/em>\uff08<em>3<\/em>\uff09 \uff09\u3002\u2f6a\u819a \u8001\u5316\u5c0e\u81f4 ECM \u548c DEJ \u767c\u2f63\u5287\u70c8\u8b8a\u5316\u3002\u9019\u4e9b\u2f63\u7269\u5b78\u8b8a\u5316\u53cd\u6620\u5728\u8001\u5316\u2f6a\u819a\u7684\u81e8\u5e8a\u75c7\u72c0\u4e0a\u3002<\/p>\n<h3>Sytenol A\u8207Retinol\u5c0d\u4ee3\u8b1d\u57fa\u56e0\u53cd\u61c9\uff1a<\/h3>\n<p>\u5be6\u9a57\u8b49\u5be6 Sytenol \u00ae A \u50cfRetinol\u2f00\u6a23\u767c\u63ee\u4f5c\u2f64\u4e14\u751a\u81f3\u6548\u679c\u66f4\u52dd\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-219 size-full\" src=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u8207-retinol-e1628864493429.jpg\" alt=\"\" width=\"640\" height=\"580\" srcset=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u8207-retinol-e1628864493429.jpg 640w, https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u8207-retinol-e1628864493429-400x363.jpg 400w\" sizes=\"auto, (max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 984px) 61vw, (max-width: 1362px) 45vw, 600px\" \/><\/p>\n<p><strong>\u7d30\u80deRetinol\u7d50\u5408\u86cb\u2f69 <\/strong><strong>(CRBP)<\/strong><strong>\uff1a<\/strong><\/p>\n<p>\u5fc5\u4e0d\u53ef\u5c11\u7684 Retinol\u548c\u8996\u9ec3\u9178\u7684\u2f63\u7269\u5408\u6210\u548cRetinol\u7684\u5132\u5b58\u3002<\/p>\n<p><strong>\u7d30\u80de\u8996\u9ec3\u9178\u7d50\u5408\u86cb\u2f69 <\/strong><strong>(CRABP)<\/strong><strong>\uff1a<\/strong><\/p>\n<p>\u5411\u4e0b Sytenol \u00ae A \u7684\u8abf\u7bc0\u6d88\u9664\u4e86\u8996\u9ec3\u9178\u8a98\u5c0e\u7684\u6bd2\u6027\u3002<\/p>\n<p><strong>N-6 <\/strong><strong>\u817a\u560c\u5464\u7279\u7570\u6027 <\/strong><strong>DNA <\/strong><strong>\u7532\u57fa\u8f49\u79fb\u9176 <\/strong><strong>2 (N6AMT2)<\/strong><strong>\uff1a <\/strong><\/p>\n<p>\u8996\u9ec3\u9178\u6297\u6027\u53ef\u80fd\u6703\u56e0\u4f7f\u2f64\u2f7d\u53d7\u5230\u6253\u64ca \u8868\u89c0\u907a\u50b3\u4fee\u98fe\u5291\uff0c\u5982 DNA \u7532\u57fa \u8f49\u79fb\u9176\u6291\u88fd\u5291\u3002N6AMT2 \u7684\u4e0b\u8abfSytenol \u00ae A \u53ef\u964d\u4f4e\u8996\u9ec3\u9178\u5f15\u8d77\u7684\u6bd2\u6027\u3002<\/p>\n<p><strong>\u4ed6\u624e\u7f85\u6c40\u8a98\u5c0e\u57fa\u56e0 <\/strong><strong>1 (TIG1)<\/strong><strong>\uff1a <\/strong>TIG1 \u4e0b\u8abf\u2f64\u65bc\u75e4\u7621\u3001\u9152\u6e23\u2fd0\u548c\u2f5c\u2f6a\u766c\u3002Sytenol \u00ae A\u7684\u4e0a\u8abf \u671f\u671b\u63d0\u4f9b\u2f6a\u819a\u76ca\u8655\u3002<\/p>\n<p><strong>Retinol<\/strong><strong>\u812b\u6c2b\u9176<\/strong><strong>\/<\/strong><strong>\u9084\u539f\u9176\uff08<\/strong><strong>RDH14<\/strong><strong>\uff1b<\/strong><strong>DHRS9<\/strong><strong>\uff1b <\/strong><strong>RETSAT<\/strong><strong>\uff09\uff1a<\/strong>\u5c07Retinol\u8f49\u5316\u70ba\u8996\u9ec3\u919b\uff0c\u7136\u5f8c\u8f49\u5316\u70ba\u8996\u9ec3<strong>\u9178<\/strong> \u9178\u3002Retinol\u98fd\u548c\u9176 (RETSAT) \u53c3\u8207\u6b63\u5e38\u5316\u8102\u80aa\u7d30\u80de\u5206\u5316\u3002<\/p>\n<p><strong>\u5375\u78f7\u8102<\/strong><strong>&#8211;<\/strong><strong>Retinol<\/strong><strong>\u9170\u57fa\u8f49\u79fb\u9176 <\/strong><strong>(LRAT)<\/strong><strong>\uff1a<\/strong><\/p>\n<p>Retinol LRAT\u8207\u2ed1\u93c8\u8102\u80aa\u9178\u916f\u5316\u662f\u95dc\u9375 Retinol\u5438\u6536\u548c\u5132\u5b58\u7684\u6b65\u9a5f\u3002<\/p>\n<p><strong>\u7d30\u80de\u2f8a\u7d20 <\/strong><strong>P450<\/strong><strong>\uff08<\/strong><strong>CYP1A1<\/strong><strong>\uff1b<\/strong><strong>CYP1A2<\/strong><strong>\uff09\uff1a <\/strong><\/p>\n<p>P450s 1A1 \u548c 1A2\u8ca0\u8cac\u5c07Retinol\u50ac\u5316\u70ba\u8996\u9ec3\u919b\uff0c\u9650\u901f\u8996\u9ec3\u9178\u7684\u2f63\u7269\u5408\u6210\u6b65\u9a5f\u3002<\/p>\n<h3>\u7d30\u80de\u5916\u57fa\u8cea\u57fa\u56e0\uff1a<\/h3>\n<p>\u5b8c\u6574\u548c\u2f54\u5408\u7684\u7d30\u80de\u5916\u57fa\u8cea\u57fa\u56e0\u5c0d\u65bc\u4fdd\u6301\u5e74\u8f15\u7684\u2f6a\u819a\u2f84\u95dc\u91cd\u8981\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-220 size-full\" src=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/steenol-a\u7d30\u80de\u5916\u57fa\u8cea-e1628864474255.jpg\" alt=\"\" width=\"640\" height=\"581\" srcset=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/steenol-a\u7d30\u80de\u5916\u57fa\u8cea-e1628864474255.jpg 640w, https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/steenol-a\u7d30\u80de\u5916\u57fa\u8cea-e1628864474255-400x363.jpg 400w\" sizes=\"auto, (max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 984px) 61vw, (max-width: 1362px) 45vw, 600px\" \/><\/p>\n<p><strong>\u81a0\u539f\u86cb\u2f69\uff1a<\/strong>\u8ca0\u8cac\u2f6a\u819a\u5f37\u5ea6\u548c\u5f48\u6027\uff1b \u9000\u5316\u5c0e\u81f4\u76ba\u7d0b\u3002<\/p>\n<p><strong>\u5f48\u6027\u7e96\u7dad\uff1a <\/strong>(1) \u5f48\u6027\u86cb\u2f69\u5fae\u7e96\u7dad (EMILIN3) \u662f\u2f00\u7a2e \u5f48\u6027\u7e96\u7dad\u7684\u7d44\u6210\u90e8\u5206\uff0c\u4e3b\u8981\u96c6\u4e2d\u5728 \u754c\u2faf\u4e26\u53c3\u8207\u5f48\u6027\u2f63\u6210\u904e\u7a0b\u3002 (2)\u539f\u7e96\u7dad\u86cb\u2f69(FBN3)\uff1a\u69cb\u6210\u4e3b\u8981\u7684\u9aa8\u67b6 \u5f48\u6027\u548c\u975e\u5f48\u6027\u7684\u591a\u529f\u80fd\u5fae\u7e96\u7dad\u3002<\/p>\n<p>\u7d30\u80de\u5916\u57fa\u8cea\u3002Sytenol \u00ae A \u53ef\u4ee5\u4fdd\u6301\u6240\u9700\u7684\u80fd\u91cf\u7dad\u6301\u9023\u63a5\u6240\u9700\u7684\u5f48\u6027\u86cb\u2f69\u2f54\u5e73 \u7531\u65bc\u5f48\u6027\u86cb\u2f69\u9176\u7684\u4e0a\u8abf\u5c0e\u81f4\u7d44\u7e54\u7a69\u614b \u6291\u88fd\u5291\uff08PI3\uff09\u3002<\/p>\n<p><strong>\u7e96\u9023\u86cb\u2f69 <\/strong><strong>(FLR3; FLR2)<\/strong><strong>\uff1a<\/strong>\u4fdd\u6301\u7d30\u80de\u7684\u5f62\u72c0\u662f\u57fa\u8cea\u7a69\u5b9a\u7684\u5148\u6c7a\u689d\u4ef6\u3002<\/p>\n<p><strong>\u73bb\u5c3f\u9178\u548c\u2f54\u901a\u9053\u86cb\u2f69\uff1a<\/strong>\u73bb\u5c3f\u9178\u8ca0\u8cac \u7dad\u6301\u2fbc\u5ea6\u2f54\u5408\u7684\u7d30\u80de\u5916\u57fa\u8cea \u5728\u7d44\u7e54\u4e2d\uff0c\u4e5f\u53c3\u8207\u7d30\u80de\u7c98\u9644\u548c\u2f40\u6301 \u7d30\u80de\u9077\u79fb\u3002\u5b83\u662f\u7531\u4e09\u500b\u4e0d\u540c\u7684\u4e4b\u2f00\u5408\u6210\u7684 \u73bb\u5c3f\u9178\u5408\u6210\u9176\uff0c\u4f8b\u5982 HAS-3\u3002\u2f54\u901a\u9053\u86cb\u2f69 3 (AQP3) \u662f\u8868\u9054\u7684\u2f54\/\u2f62\u6cb9\u8f49\u904b\u901a\u9053\u86cb\u2f69 \u5728\u8868\u2f6a\u4e2d\uff0c\u6709\u52a9\u65bc\u4fdd\u6301\u9069\u7576\u7684\u2f6a\u819a\u2f54\u5e73\u2f54\u5408\u4f5c\u2f64\u3001\u5f48\u6027\u548c\u5c4f\u969c\u6062\u5fa9\u3002AQP3\u86cb\u2f69 \u901a\u904e\u4f7f\u2f64 EpidermFT \u5168\u539a\u5ea6\u78ba\u8a8d\u523a\u6fc0\u2f6a\u819a\u3002<\/p>\n<h3>\u771f\u2f6a\u8868\u2f6a\u9023\u63a5\u57fa\u56e0\uff1a<\/h3>\n<p>\u771f\u2f6a &#8211; \u8868\u2f6a\u9023\u63a5\u57fa\u56e0\u8655\u7684\u5b8c\u6574\u57fa\u5e95\u819c\u5c0d\u65bc\u4fdd\u6301\u5e74\u8f15\u7684\u2f6a\u819a\u2f84\u95dc\u91cd\u8981\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-221 size-full\" src=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u771f\u76ae\u8868\u76ae-e1628864449135.jpg\" alt=\"\" width=\"640\" height=\"564\" srcset=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u771f\u76ae\u8868\u76ae-e1628864449135.jpg 640w, https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u771f\u76ae\u8868\u76ae-e1628864449135-400x353.jpg 400w\" sizes=\"auto, (max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 984px) 61vw, (max-width: 1362px) 45vw, 600px\" \/><\/p>\n<p><strong>IV<\/strong><strong>\u578b\u81a0\u539f\u86cb\u2f69\uff1a <\/strong>IV\u578b\u81a0\u539f\u86cb\u2f69\u5f62\u6210\u8d85\u5206\u2f26\u7db2\u7d61\uff0c\u5f71\u97ff\u7d30\u80de\u7c98\u9644\u3001\u9077\u79fb\u548c\u5206\u5316\u3002<\/p>\n<p><strong>XVII <\/strong><strong>\u578b\u81a0\u539f\u86cb\u2f69\uff1a <\/strong>XVII \u578b\u662f\u95dc\u9375\u9328\u5b9a\u4e4b\u2f00\u5f37\u5316\u8868\u2f6a\u8207\u2f6a\u819a\u7684\u9644\u8457\u7684\u539f\u7e96\u7dad\u771f\u2f6a\u3002<\/p>\n<p><strong>\u5c64\u7c98\u9023\u86cb\u2f69\uff08<\/strong><strong>LAMA3<\/strong><strong>\u548c<\/strong><strong>LAMC2<\/strong><strong>\uff09\uff1a<\/strong>\u5c64\u7c98\u9023\u86cb\u767d\u662f\u7d30\u80de\u5916\u57fa\u8cea\u7684\u9ad8\u5206\u5b50\u91cf\u86cb\u767d\u8cea\u3002 \u5b83\u5011\u662f\u57fa\u5e95\u5c64\u7684\u4e3b\u8981\u6210\u5206\uff0c\u662f\u5927\u591a\u6578\u7d30\u80de\u548c\u5668\u5b98\u7684\u4e00\u500b\u86cb\u767d\u8cea\u7db2\u7d61\u57fa\u790e\u3002\u4e3b\u8981\u7684\u975e\u81a0\u539f\u86cb\u2f69 \u57fa\u5e95\u5c64\u3002\u53c3\u8207\u7d30\u80de\u5206\u5316\u3001\u9077\u79fb\u3001 \u7c98\u9644\u4ee5\u53ca\u8868\u578b\u548c\u5b58\u6d3b\u7387\u3002<\/p>\n<p><strong>Integrin<\/strong><strong>\uff08<\/strong><strong>ITGB4<\/strong><strong>\u3001<\/strong><strong>ITGB6<\/strong><strong>\u3001<\/strong><strong>ITGB8<\/strong><strong>\u3001<\/strong><strong>ITGA6<\/strong><strong>\uff09\uff1a<\/strong>\u5b9a\u7fa9\u8702\u7aa9 \u5f62\u72c0\u3001\u6d41\u52d5\u6027\u548c\u8abf\u7bc0\u7d30\u80de\u9031\u671f\uff1b\u4e3b\u8981\u529f\u80fd- \u7d30\u80de\u8207 ECM \u7684\u9023\u63a5\u548c\u4fe1\u865f\u8f49\u5c0e ECM \u5230\u7d30\u80de\u3002<\/p>\n<p><strong>ECM <\/strong><strong>\u86cb\u2f69 <\/strong><strong>(ECM)<\/strong><strong>\uff1a<\/strong>\u53c3\u8207\u57fa\u5e95\u819c\u548c \u81a0\u539f\u7e96\u7dad\u5b8f\u89c0\u7d44\u88dd\u548c\u2f63\u2ed1\u56e0\u2f26\u7d50\u5408\u3002<\/p>\n<p><strong>Dystroglycan (DAG2)<\/strong><strong>\uff1a<\/strong>\u53c3\u8207\u7d44\u88dd\u548c \u57fa\u5e95\u819c\u7d50\u69cb\u7684\u7dad\u8b77\uff1b\u640d\u5931\u539f\u56e0 \u8868\u2f6a\u5206\u5316\u7684\u7834\u58de\u3002<\/p>\n<p><strong>E-Cadherin (CDH1)<\/strong><strong>\uff1a<\/strong>\u53c3\u8207\u7dca\u5bc6\u9023\u63a5\u7684\u5f62\u6210&amp; \u7dad\u6301\u5e79\u7d30\u80de\u7684\u591a\u80fd\u6027\uff1b\u7576\u592a\u967d\u904e\u5ea6\u66dd\u5149 \u6642\u6703\u5c0e\u81f4 CDH1 \u6d41\u5931\u3002<\/p>\n<h2><strong>\u7522\u54c1\u80cc\u5f8c\u7684\u79d1\u5b78\u2014\u9810\u9632\u6027\u6297\u8870\u8001<\/strong><\/h2>\n<p>\u53ca\u65e9\u91dd\u5c0d\u808c\u819a\u554f\u984c\uff0c\u6709\u6548\u9632\u2f4c\u808c\u819a\u53d7\u640d\uff0c\u6539\u5584\u819a\u8cea\u3002\u5ef6\u7de9\u8870\u8001\u904e\u7a0b\u53ef\u4ee5\u901a\u904e\u3002<\/p>\n<ol>\n<li>\u6297\u6c27\u5316\u4fdd\u8b77\u4f86\u9650\u5236\u5c0d\u7d30\u80de\u3001\u86cb\u2f69\u8cea\u548c DNA \u7684\u76f4\u63a5\u6c27\u5316\u640d\u50b7\u3002<\/li>\n<li>\u63a7\u5236\u708e\u75c7\u4ee5\u6700\u2f24\u9650\u5ea6\u5730\u6e1b\u5c11\u708e\u75c7\u8001\u5316\u3002<\/li>\n<li>\u964d\u4f4e\u57fa\u8cea\u2fa6\u5c6c\u86cb\u2f69\u9176\u6d3b\u6027\u4ee5\u4fdd\u8b77 ECM \u548c DEJ \u86cb\u2f69\u3002<\/li>\n<\/ol>\n<h3>\u9632\u79a6\u6c27\u5316\u61c9\u6fc0<\/h3>\n<p>\u2f83\u7531\u57fa\u2f32\u64fe\u7d30\u80de\u529f\u80fd\u7684\u6a5f\u5236\u548c\u4e8b\u4ef6\u9806\u5e8f\u5c1a\u4e0d\u5b8c\u5168\u6e05\u695a\uff1b\u4f46\u5176\u4e2d\u4e4b\u2f00 \u6700\u91cd\u8981\u7684\u4e8b\u4ef6\u4f3c\u4e4e\u662f\u8102\u8cea\u904e\u6c27\u5316\uff0c\u9019\u6703\u5c0e\u81f4\u7d30\u80de\u819c\u640d\u50b7\u3002\u9019\u7a2e\u640d\u58de\u6703\u5c0e\u81f4\u7db2\u7d61\u767c\u2f63\u8b8a\u5316 \u7d30\u80de\u7684\u96fb\u8377\uff0c\u6539\u8b8a\u6ef2\u900f\u58d3\uff0c\u5c0e\u81f4\u816b\u8139\u4e26\u6700\u7d42\u5c0e\u81f4\u7d30\u80de\u6b7b\u4ea1\uff08<em>Nijvelt <\/em>\u7b49\uff0c<em>Am J Clin Nutr, 74(4):418-425,2001 <\/em>\u5e74\uff09\u3002Sytenol \u00ae A \u662f\u2f00\u7a2e\u5ee3\u8b5c\u6297\u6c27\u5316\u5291\uff0c\u5177\u6709\u51fa\u2f8a\u7684\u8102\u8cea\u904e\u6c27\u5316\u6291\u5236\u6d3b\u6027 ( <em>Chaudhuri &amp; Bou, C&amp;T, 130:63-75, 2015 <\/em>) &amp; \u80fd\u5920\u523a\u6fc0\u6297\u6c27\u5316\u9632\u79a6\u7cfb\u7d71 ( <em>Chaudhuri, EuroCosmetics, 11-12:20-24, 2015 <\/em>)\u3002\u9019\u7a2e\u96d9\u91cd\u6297\u6c27\u5316\u9014\u5f91 Sytenol \u00ae A \u6709\u52a9\u65bc\u7dad\u6301\u8102\u8cea\u9ad4\u5167\u5e73\u8861\uff0c\u5f9e\u2f7d\u4fdd\u8b77\u2f6a\u819a\u514d\u53d7\u6c27\u5316\u640d\u50b7\u3002\u56de\u9867\u201c\u8102\u8cea\u904e\u6c27\u5316\u7684\u5f8c\u679c\u5728 Sytenol \u00ae A \u6297\u7c89\u523a\u2f3f\u518a\u4e2d\u3002<\/p>\n<p>\u6e05\u9664\u2f83\u7531\u57fa\u548c\u975e\u2f83\u7531\u57fa<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-222 size-full\" src=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u6e05\u9664\u81ea\u7531\u57fa-e1628864424179.jpg\" alt=\"\" width=\"640\" height=\"87\" srcset=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u6e05\u9664\u81ea\u7531\u57fa-e1628864424179.jpg 640w, https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u6e05\u9664\u81ea\u7531\u57fa-e1628864424179-400x54.jpg 400w\" sizes=\"auto, (max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 984px) 61vw, (max-width: 1362px) 45vw, 600px\" \/><\/p>\n<p>(1 )\u00b5mole Trolox \u7576\u91cf\/g\u3002<\/p>\n<p>(2)\u2f93\u9bca\u70ef\u4f5c\u70ba\u8102\u8cea\u904e\u6c27\u5316\u6291\u5236\u6d3b\u6027\u7684\u5e95\u7269\uff1b\u6578\u64da\u4ee5 IC 50\u8868\u2f70\uff0c\u55ae\u4f4d\u70ba \u00b5g\/ml\uff1b\u6bd4\u2f63\u80b2\u915a\u6709\u6548 60 \u500d\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-223 size-full\" src=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u500d\u6578\u8b8a\u5316-e1628864409799.jpg\" alt=\"\" width=\"640\" height=\"505\" srcset=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u500d\u6578\u8b8a\u5316-e1628864409799.jpg 640w, https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u500d\u6578\u8b8a\u5316-e1628864409799-400x316.jpg 400w\" sizes=\"auto, (max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 984px) 61vw, (max-width: 1362px) 45vw, 600px\" \/><\/p>\n<p><strong>\u6297\u6c27\u5316\u9632\u79a6\u57fa\u56e0\u7684\u4e0a\u8abf<\/strong><strong>\u6e2c\u8a66\u65b9\u6cd5\uff1a<\/strong><\/p>\n<p>\u4f7f\u2f64\u5168\u539a\u5ea6\u8868\u2f6a\u7d44\u7e54 (Mattek) \u9032\u2f8f DNA \u5fae\u9663\u5217\u6e2c\u8a66<\/p>\n<ul>\n<li>Retinol\u548c Sytenol \u00ae A \u6eb6\u89e3\u5728 DMSO \u4e2d\uff0c\u9032\u2f00\u6b65\u7a00\u91cb\u5728\u2f54\u4e2d\u4e26\u61c9\u2f64\u65bc\u5168\u5c64\u8868\u2f6a\u7d44\u7e54\u3002<\/li>\n<li>\u57f9\u990a\u5169\u5929\u3002<\/li>\n<li>\u9078\u64c7\u7684\u57fa\u56e0\u8868\u9054\u5177\u6709 &gt;\u00b1 2 \u500d\u7684\u8b8a\u5316\u3002<\/li>\n<li>\u7d71\u8a08\u986f\u8457\u6027\uff1ap = \u22640.05\u3002<\/li>\n<\/ul>\n<h3>\u6297\u6c27\u5316\u9632\u79a6\u57fa\u56e0\u7684\u4f5c\u2f64<\/h3>\n<ul>\n<li>\u7a40\u80f1\u2f62\u80bd\u904e\u6c27\u5316\u7269\u9176 (GPX3)\uff1a\u6e1b\u5c11\u8102\u8cea\u904e\u6c27\u5316\u7269 \u8f49\u5316\u70ba\u76f8\u61c9\u7684\u9187\u4e26\u6e1b\u5c11\u6e38\u96e2\u6c2b\u904e\u6c27\u5316\u7269\u8f49\u8b8a\u6210\u2f54\u3002<\/li>\n<li>\u7a40\u80f1\u2f62\u80bd S-\u8f49\u79fb\u9176\uff08GSST1 \u548c GSTP1\uff09\uff1a\u8abf\u7bc0 \u8102\u8cea\u904e\u6c27\u5316\u7522\u7269\u7684\u7d30\u80de\u5167\u6fc3\u5ea6\u3002<\/li>\n<\/ul>\n<h3>\u4fdd\u8b77\u7dda\u7c92\u9ad4\u548c\u589e\u52a0 ATP \u5408\u6210<\/h3>\n<p>\u8a31\u591a\u7814\u7a76\u5df2\u7d93\u78ba\u5b9a\uff0c\u6c27\u5316\u61c9\u6fc0\u548c\u7dda\u7c92\u9ad4\u529f\u80fd\u969c\u7919\u662f\u5c0e\u81f4\u8870\u8001\u904e\u7a0b\u7684\u5169\u500b\u6838\u2f3c\u56e0\u7d20\u3002 \u7dda\u7c92\u9ad4\u2f63\u7269\u767c\u2f63\u6d89\u53ca\u591a\u500b\u9700\u8981\u7dca\u5bc6\u5354\u8abf\u7684\u904e\u7a0b\u3002PGC-1\u03b1 \u662f\u7dda\u7c92\u9ad4\u7684\u4e3b\u8981\u8abf\u7bc0\u56e0\u2f26\u2f63\u7269\u767c\u2f63\u4e26\u986f\u2f70\u53d7\u88dc\u9aa8\u8102\u915a\u523a\u6fc0\uff08<em>Seo et al., Evid Based Complement Altern Med, article ID 678028, 2013<\/em>\uff09\u3002\u88dc\u9aa8\u8102\u915a\u662f \u986f\u2f70\u5728\u4fdd\u8b77\u7dda\u7c92\u9ad4\u529f\u80fd\u514d\u53d7\u6c27\u5316\u61c9\u6fc0\u2f45\u2faf\u975e\u5e38\u6709\u6548\uff08<em>Haraguchi et al., Planta Med, 16:539-544, 2002)<\/em>\uff0c \u4ee5\u6642\u9593\u4f9d\u8cf4\u6027\u2f45\u5f0f\u9632\u2f4c\u7dda\u7c92\u9ad4\u8102\u8cea\u904e\u6c27\u5316\u548c\u6291\u5236\u6e90\u2f83\u8102\u8cea\u904e\u6c27\u5316\u7684\u6c27\u6d88\u8017\u3002 \u88dc\u9aa8\u8102\u915a\u88ab\u8b49\u660e\u53ef\u4ee5\u4fdd\u8b77\u7dda\u7c92\u9ad4\u547c\u5438\u9176\u6d3b\u6027\u514d\u53d7 NADPH \u4f9d\u8cf4\u6027\u548cdihydroxyfummarate\u8a98\u5c0e\u904e\u6c27\u5316\u640d\u50b7\u7684\u5f71\u97ff\u3002\u64da\u5831\u5c0e\uff0c\u88dc\u9aa8\u8102\u915a\u53ef\u589e\u52a0\u56e0 H 2 O 2\u8655\u7406\u2f7d\u6e1b\u5c11 ATP \u5408\u6210\u7684\u8001\u5e74\u2f29\u9f20\u809d\u7d30\u80de\u4e2d\u7684 ATP \u5408\u6210 \u4e26\u9632\u2f4c\u7dda\u7c92\u9ad4\u57fa\u56e0\u7d44\u640d\u50b7\uff08<em>Tsujimoto et al, Apoptosis, 12(5):835-840, 2007; Seo etl al., Evid Based Complement AlternMed, article ID 678028, 2013<\/em>\uff09\u3002<\/p>\n<h3>\u9632\u79a6\u708e\u75c7<\/h3>\n<p>\u2f6a\u819a\u8001\u5316\u548c\u708e\u75c7\u5bc6\u5207\u76f8\u95dc\u3002\u708e\u75c7\u8a98\u5c0e\u7684\u8870\u8001\u904e\u7a0b\u6d89\u53ca\u2f00\u500b\u2fbc\u5ea6\u8907\u96dc\u7684\u4e8b\u4ef6\u93c8\uff0c\u901a\u904e \u6025\u6027\u708e\u75c7\u9010\u6f38\u8b93\u4f4d\u65bc\u6162\u6027\u6216\u7121\u75c7\u72c0\u708e\u75c7\u3002\u6b63\u662f\u9019\u7a2e\u6f5b\u5728\u7684\u708e\u75c7\u6700\u7d42\u4f7f\u2f08\u7b4b\u75b2\u2f12\u76e1\u2f9d\u9ad4\u7684\u9632\u79a6\u7cfb\u7d71\u5c0e\u81f4\u81a0\u539f\u86cb\u2f69\u548c\u5f48\u6027\u86cb\u2f69\u964d\u89e3\u4ee5\u53ca\u2f6a\u819a\u5c4f\u969c\u529f\u80fd\u7684\u7834\u58de\uff08<em>Woods et al., Aging <\/em><em>Dis, 3(1):130-140, 2012 <\/em>)\u3002\u4fb5\u8755\u2f6a\u819a\u7d50\u69cb\u7684\u708e\u75c7\u7d1a\u806f\u53cd\u61c9\u2014\u2014\u6700\u7d42\u5f62\u6210\u6df1\u76ba\u7d0b\u3001\u2f8a\u7d20\u6c89\u8457\u904e\u5ea6 \u548c\u975e\u5f48\u6027\u7d44\u7e54\u3002Sytenol \u00ae A \u901a\u904e\u6291\u5236\/\u4e0b\u8abf\u4fc3\u708e\u57fa\u56e0\u548c\u9176\u4f86\u63a7\u5236\u708e\u75c7(Chaudhuri, In Cosmecuticals and Active Cosmetics, 3rd edition, Eds. Maibach et al., Chapter 1, 1-8, 2015)\u3002<\/p>\n<h3>\u4fc3\u708e\u57fa\u56e0\u7684\u4e0b\u8abf \u5354\u8b70\uff1a<\/h3>\n<p>\u4f7f\u2f64\u5168\u539a\u5ea6\u8868\u2f6a\u7d44\u7e54 (Mattek) \u9032\u2f8f DNA \u5fae\u9663\u5217\u6e2c\u8a66\u3002<\/p>\n<ul>\n<li>Retinol\u548c Sytenol \u00ae A \u6eb6\u89e3\u5728 DMSO \u4e2d\uff0c\u9032\u2f00\u6b65\u7a00\u91cb\u5728\u2f54\u4e2d\u4e26\u61c9\u2f64\u65bc\u5168\u5c64\u8868\u2f6a\u7d44\u7e54\u3002<\/li>\n<li>\u57f9\u990a 48 \u2f29\u6642\u3002<\/li>\n<li>\u9078\u64c7\u7684\u57fa\u56e0\u8868\u9054\u5177\u6709 &gt;\u00b1 2 \u500d\u7684\u8b8a\u5316\u3002<\/li>\n<li>\u7d71\u8a08\u986f\u8457\u6027\uff1ap = \u22640.05\u3002<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-224 size-full\" src=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u57fa\u56e0\u63cf\u8ff0-e1628864380629.jpg\" alt=\"\" width=\"640\" height=\"142\" srcset=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u57fa\u56e0\u63cf\u8ff0-e1628864380629.jpg 640w, https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u57fa\u56e0\u63cf\u8ff0-e1628864380629-400x89.jpg 400w\" sizes=\"auto, (max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 984px) 61vw, (max-width: 1362px) 45vw, 600px\" \/><\/p>\n<p>* HPGD \u662f\u2f00\u7a2e\u5206\u89e3\u4ee3\u8b1d\u9176\uff0c\u901a\u904e\u5c07\u524d\u5217\u817a\u7d20\u8f49\u5316\u70ba\u7121\u6d3b\u6027\u7684\u916e\u4ee3\u8b1d\u7269\u4f86\u63a7\u5236\u524d\u5217\u817a\u7d20\u7684\u2f63\u7269\u6d3b\u6027\u3002<\/p>\n<h3>\u6291\u5236\u4fc3\u708e\u9176<\/h3>\n<p>Sytenol \u00ae A \u5c0d\u4fc3\u708e\u9176\u5177\u6709\u6291\u5236\u6d3b\u6027\uff1a<\/p>\n<p>&#8211; \u78f7\u8102\u9176 A2 (PLA2)\u3001COX \u548c LOX \u4ee5\u53ca\u5291\u91cf\u4f9d\u8cf4\u6027 \u6e1b\u5c11 LTB4 \u548c TXB2 \u7684\u5f62\u6210\uff08<em>Ferrandiz et al., J Pharm <\/em><em>Pharmacol, 48(9):975-980, 1996 <\/em>)\u3002<\/p>\n<p>Sytenol \u00ae A \u53ef\u6709\u6548\u6291\u5236COX-1 IC 50 14.7 \u00b5g\/ml) \u548c COX-2 (IC 50 514 \u00b5g\/ml) \u6d3b\u6027\u3002<\/p>\n<p>\u6709\u8da3\u7684\u662f\uff0c\u5728\u8f03\u2fbc\u5291\u91cf (50 \u00b5g\/ml) \u4e0b\uff0cRetinol\u6703\u4fc3\u9032 COX-2\u6d3b\u6027\uff0c\u2f7d Sytenol \u00ae A \u5c07\u6d3b\u6027\u964d\u4f4e\u4e86 40% ( <em>Chaudhuri<\/em><em>&amp; Marchio, Cosmet &amp;Toilet, 126(7):502-510, 2011 <\/em>)\u3002\u6587\u737b\u4e5f\u8868\u660e Sytenol \u00ae A \u5177\u6709\u6291\u5236\u8102\u52a0\u6c27\u9176 (LOX)\u6d3b\u6027( <em>Ferrandiz et al., J Pharm Pharmacol, 48(9):975-980, 1996).<\/em>\u3002<\/p>\n<p><strong>\u9632\u79a6\u57fa\u8cea\u2fa6\u5c6c\u86cb\u2f69\u9176 <\/strong><strong>(MMP)<\/strong><\/p>\n<p>MMPs \u5728\u5f71\u97ff\u771f\u2f6a\u7d50\u69cb\u5b8c\u6574\u6027\u7684\u86cb\u2f69\u8cea\u548c\u81a0\u539f\u86cb\u2f69\u964d\u89e3\u4e2d\u8d77\u4e3b\u8981\u4f5c\u2f64\u3002\u5728\u6b63\u5e38\u2f6a\u819a\u4e2d\uff0c\u5b83\u7684\u7522\u2f63 \u8207\u5b83\u5011\u7684\u5929\u7136\u6291\u88fd\u5291 (TIMP) \u4fdd\u6301\u5e73\u8861\uff1b\u7136\u2f7d\uff0c\u64da\u5831\u5c0e\u7d2b\u5916\u7dda\u6703\u589e\u52a0\u2f08\u9ad4\u2f6a\u819a\u4e2d MMP \u7684\u5408\u6210 \u5c0e\u81f4\u9ad4\u5167\u81a0\u539f\u86cb\u2f69\u7834\u58de\uff0c\u5c0e\u81f4 MMP \u8207\u5176\u5929\u7136\u6291\u88fd\u5291 (TIMP) \u4e4b\u9593\u7684\u4e0d\u5e73\u8861\uff0c\u5f9e\u2f7d\u5c0e\u81f4 \u7d50\u7de0\u7d44\u7e54\u7684\u52a0\u901f\u7834\u58de\u548c\u5149\u8001\u5316\uff08<em>Fisher et al., New Engl J Med, 337:1219-1228,1997<\/em>\uff09\u3002\u56e0\u6b64\u6e1b\u5c11 MMPs \u6709\u671b\u5ef6\u7de9\u2f6a\u819a\u8001\u5316\u7684\u81e8\u5e8a\u8868\u73fe\u3002<\/p>\n<p>\u9451\u65bcRetinol\u548c Sytenol \u00ae A\u7684\u8a31\u591a\u76f8\u4f3c\u2f6c\u6a19\uff0c\u6211\u5011\u6bd4\u8f03\u4e86\u5b83\u5011\u5728\u5169\u500b\u95dc\u9375\u57fa\u8cea\u4e0a\u7684 Sytenol \u00ae A \u548cRetinol\u7684\u6027\u80fd\u2fa6\u5c6c\u86cb\u2f69\u9176\u3001MMP-1 \u548c MMP-12\u3002\u5982\u4e0b\u8868\u6240\u2f70\uff0cSytenol \u00ae A \u5c0d MMP-1 \u548c\u5c0d MMP-12 \u7684\u6291\u88fd\u4f5c\u2f64\u660e\u986f\u66f4\u5f37\uff0c\u9060\u9060\u8d85\u904eRetinol\u7684\u4f5c\u2f64\uff08<em>Chaudhuri, In Cosmeceuticals and Active Cosmetics, Eds.<\/em><em>Maibach et al, Chapter 1, 1-18, 2015<\/em>\uff09\u3002\u56e0\u6b64\uff0c\u9810\u8a08 Sytenol \u00ae A \u5c07\u70ba\u7d30\u80de\u5916\u57fa\u8cea\u86cb\u2f69\u63d0\u4f9b\u66f4\u5f37\u7684\u4fdd\u8b77 \u9ad4\u5167\u6297MMPs\u3002<\/p>\n<h3>\u57fa\u8cea\u2fa6\u5c6c\u86cb\u2f69\u9176\u6d3b\u6027\u7684\u6291\u5236<\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-225 size-full\" src=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u57fa\u8cea\u91d1\u5c6c\u86cb\u767d\u9176-e1628864356939.jpg\" alt=\"\" width=\"640\" height=\"81\" srcset=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u57fa\u8cea\u91d1\u5c6c\u86cb\u767d\u9176-e1628864356939.jpg 640w, https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u57fa\u8cea\u91d1\u5c6c\u86cb\u767d\u9176-e1628864356939-400x51.jpg 400w\" sizes=\"auto, (max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 984px) 61vw, (max-width: 1362px) 45vw, 600px\" \/><\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u660e\u53ef\u4fdd\u8b77\u2f6a\u819a\u514d\u53d7\u7d2b\u5916\u7dda\u640d\u50b7<\/strong><\/p>\n<p>\u7d05\u6591\u662f\u7d2b\u5916\u7dda\u8f3b\u5c04\u66b4\u9732\u6700\u5e38\u2f92\u7684\u8868\u73fe\uff0c\u4ee5\u96d9\u76f8\u2f45\u5f0f\u767c\u2f63\u3002UVA \u4ecb\u5c0e\u4e86\u8a72\u53cd\u61c9\u7684\u65e9\u671f\u90e8\u5206\uff0c \u7a31\u70ba\u7acb\u5373\u2f8a\u7d20\u8b8a\u2fca (IPD)\uff0c\u6301\u7e8c\u7d04\u534a\u2f29\u6642\u3002\u5ef6\u9072\u6027\u7d05\u6591\uff0c\u4e3b\u8981\u662f UV-B \u5291\u91cf\u7684\u2f00\u500b\u529f\u80fd\uff0c\u958b\u59cb \u66b4\u9732\u5f8c2-8\u2f29\u6642\uff0c24-36\u2f29\u6642\u9054\u5230\u6700\u2f24\u503c\uff0c\u66b4\u9732\u90e8\u4f4d\u51fa\u73fe\u7d05\u6591\u3001\u7619\u7662\u3001\u75bc\u75db\u3002\u2f00\u5291UVB\u2f9c\u4ee5\u5728\u2f08\u9ad4\u2f6a\u819a\u4e2d\u8a98\u767c\u7d05\u6591\u7684\u8f3b\u5c04\u5c0e\u81f4\u6bcf 106 \u500b\u6838\u82f7\u9178\u5f62\u6210\u7d04 20 \u500b\u5149\u7522\u7269\u3002<\/p>\n<p><strong>\u5be6\u9a57\u65b9\u6cd5\uff1a<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-226 size-full\" src=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u5be6\u9a57\u65b9\u6cd5-e1628864312966.jpg\" alt=\"\" width=\"640\" height=\"132\" srcset=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u5be6\u9a57\u65b9\u6cd5-e1628864312966.jpg 640w, https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u5be6\u9a57\u65b9\u6cd5-e1628864312966-400x83.jpg 400w\" sizes=\"auto, (max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 984px) 61vw, (max-width: 1362px) 45vw, 600px\" \/><\/p>\n<p><strong>\u7d50\u679c<\/strong><\/p>\n<p>\u5982\u4e0b\u8868\u6240\u2f70\uff0c\u6e05\u695a\u5730\u8868\u660e\u7d05\u6591\u7684\u8868\u73fe\u660e\u986f\u6e1b\u5c11\uff0c\u5728\u4f7f\u2f64\u542b\u6709Sytenol \u00ae A \u7684\u5340\u57df\u4e2d\uff0cL-\u3001a- \u548c ITA \u503c\u7684 delta\uff08\u6216\u8b8a\u5316\uff09\u8207\u672a\u8655\u7406\u5340\u57df\u76f8\u6bd4\u5e7e\u4e4e\u6c92\u6709\u5dee\u7570\u3002<\/p>\n<h3>\u4f7f\u2f64 1% Sytenol\u00ae A \u4e73\u6db2\uff08\u7121\u9632\u66ec\u971c\uff09\u6e1b\u5c11\u7d05\u6591<\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-227 size-full\" src=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u6e1b\u5c11\u7d05\u6591-1-e1628864284919.jpg\" alt=\"\" width=\"640\" height=\"144\" srcset=\"https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u6e1b\u5c11\u7d05\u6591-1-e1628864284919.jpg 640w, https:\/\/taiwancosmetic.org\/wp-content\/uploads\/2021\/08\/Sytenol-A-\u6e1b\u5c11\u7d05\u6591-1-e1628864284919-400x90.jpg 400w\" sizes=\"auto, (max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 984px) 61vw, (max-width: 1362px) 45vw, 600px\" \/><\/p>\n<h2><strong>\u914d\u2f45\u6307\u5357<\/strong><\/h2>\n<p>Sytenol \u00ae A \u662f\u2f00\u7a2e\u89aa\u8102\u6027\u5316\u5408\u7269\uff0c\u53ef\u8207\u591a\u7a2e\u6cb9\u8102\u6df7\u6eb6\uff0c\u4f8b\u5982\u8f9b\u9178\/\u7678\u9178\u2f62\u6cb9\u4e09\u916f\u3001\u4e9e\u6cb9\u9178\u2f04\u916f\u3001C12-15 \u70f7\u57fa \u82ef\u7532\u9178\u916f\u3001\u2f93\u9bca\u70f7\u3001\u8377\u8377\u5df4\u6cb9\u3001\u6a44\u6b16\u6cb9\u7b49\u3002 Sytenol \u00ae A \u53ef\u4ee5\u5f88\u5bb9\u6613\u5730\u914d\u88fd\u6210\u2faf\u971c\u3001\u4e73\u6db2\u3001\u6cb9\u3001\u7cbe\u83ef\u6db2\u3001\u2f54\u9187\u5674\u9727\u5291\u7b49\u3002<\/p>\n<ul>\n<li>Sytenol \u00ae A \u7684\u5efa\u8b70\u2f64\u91cf\u61c9\u70ba 0.5 \u2f84 1.0% (w\/w)\u3002<\/li>\n<li>\u2f64\u542b\u6cb9\u91cf\u7684\u4e73\u6db2\u88fd\u6210\u4e73\u6db2\u5f8c\uff0c\u5c07 Sytenol \u00ae A\u6dfb\u52a0\u5230\u914d\u2f45\u4e2d\u3002 \u52a0\u5165\u6eab\u5ea6\u9808\u4f4e\u65bc 50 \u5ea6C\u3002\u6216\u8005\uff0cSytenol \u00ae A \u53ef\u4ee5\u6dfb\u52a0\u5728\u6cb9\u76f8\u4e2d\u3002<\/li>\n<li>\u6dfb\u52a0\u5c11\u91cf\u87af\u5408\u5291 (0.05%) \u6709\u52a9\u65bc \u514b\u670d\u56e0\u9435\u6216\u9285\u7684\u5b58\u5728\u2f7d\u5c0e\u81f4\u7684\u8b8a\u2f8a\u554f\u984c\u3002<\/li>\n<li>\u6210\u54c1\u5fc5\u9808\u5448\u9178\u6027\uff0cpH \u503c\u6700\u597d\u4f4e\u65bc 6\u3002<\/li>\n<li>\u4e26\u4e14\u5fc5\u9808\u907f\u514d\u2ed1\u6642\u9593\u66b4\u9732\u5728\u71b1\u548c\u5149\u4e0b\uff0c\u2ed1\u671f\u4fdd\u6301\u7522\u54c1\u5b8c\u6574\u6027\u3002<\/li>\n<\/ul>\n<h1>\u4e3b\u8981\u51fa\u7248\u7269<\/h1>\n<ol>\n<li>S Dhaliwal et al., Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoaging, British J Dermatology, 2018 Jun 27. doi: 10.1111\/bjd.16918<\/li>\n<\/ol>\n<ol start=\"2\">\n<li>RK Chaudhuri, Bakuchiol; A retinol-like functional compound modulating multiple retinol and non-retinol targets, In Cosmeceuticals and Active Cosmetics, 3r Edition, Eds., RK Sivamani, J Jagdeo, P Elsner &amp; HI Maibach, Francis &amp; Taylor, Boca Raton, Chapter 1, 1-18, 2015<\/li>\n<\/ol>\n<ol start=\"3\">\n<li>RK Chaudhuri &amp; B Ou, Bakuchiol to stabilize retinol and polyunsaturated lipids, Cosm &amp; Toil, 130:64-75, 2015<\/li>\n<li>RK Chaudhuri &amp; K Bojanowski, Bakuchiol: A retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects, International J Cosmetic Science, 36(3):221-230, 2014<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u6295\u7a3f\u6587\u7ae0\uff0c\u4f5c\u8005\uff1a\u53f0\u7063\u5927\u660c\u83ef\u5609\u80a1\u4efd\u6709\u9650\u516c\u53f8\u3002 Sytenol\u00ae A \u00a0\u5f9e2018\u5e74\u958b\u59cbBakuchiol\u958b\u59cb\u88ab\u5927 &hellip; <a href=\"https:\/\/taiwancosmetic.org\/?p=209\" class=\"more-link\">\u95b1\u8b80\u5168\u6587<span class=\"screen-reader-text\">\u3008Sytenol\u00ae 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